FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 dormulasi of the drug was dissolved in 50 ml methanol and National Center for Biotechnology InformationU. Quantity of zeta potential can indicate the potential stability of the colloidal system, if the particles have a large positive or negative zeta potential they will have a tendency to repel each other and in too low zeta potentials particles will accumulate and attract each other.

A sample viscosity curve for formulated suspension. The authors would like to thank Dana Pharmaceutical Co. From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1.

In Figure 1 the percentage of release in all the formulations are presented. According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market.

After selecting fofmulasi acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed. For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added.

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Journal List Adv Pharm Bull v. For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes.

Please review our privacy policy. The degrees of flocculation were also equal to 1.

All other chemicals were purchased fromMerck, Darmstadt, Germany. Published online Dec Assay test Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 mg of the drug was dissolved in 50 ml methanol and Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat firmulasi healthy volunteers.

The charge of the particles effects their distribution in forumlasi environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer. Received Aug 28; Accepted Nov Open in a separate window. From all 33 formulations, only 9 were selected to further investigation.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Discussion General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability. Percent of labeled amount. Table 2 Results of assay test. Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

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Influence of the soluble solids on the zeta potential of the cloudy apple juice. According to these properties a general discussion is presented. The potential of the moving layer around each particle is called zeta potential.

Support Center Support Center. Since cefuroxime is not absorbed orally, the 1-acetyloxyethyl axetil ester of cefuroxime was used to improve its gastrointestinal absorption. Conclusion According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Percentage of release for all selected formulations. Also the system was found to be time-depended. Pharmacokinetic models for the saturable absorption of cefuroxime axetil and susprnsion elimination of cefuroxime axetil. Acknowledgement The authors would like to thank Dana Pharmaceutical Co. A sample of these curves is shown in Figure 2.