1 Nov Find important safety information and patient resources for all of our currently marketed medicines. Updates Package Inserts – Jan Vials Packaging Change – Aug PEGASYS® (peginterferon alfa-2a), as part of a combination regimen with other. 11 Mar PEGASYS: Peginterferon alfa-2a is a covalent conjugate of recombinant leukocyte interferon gene inserted into and expressed in E. coli.
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Patients should be thoroughly instructed in the importance of proper disposal and cautioned against any reuse of any needles, syringes and autoinjectors. Interferon alfa-2a is produced using recombinant DNA pegasys package insert in which a cloned human leukocyte interferon gene is inserted into and expressed in Escherichia coli. The safety and efficacy of telbivudine in combination with interferons for the treatment of CHB pegasys package insert not been demonstrated. Hemodialysis and peritoneal dialysis are not effective.
Do not inject air into the fluid see Figure F.
The apparent clearance of peginterferon alfa-2a was similar between subjects with ESRD and subjects with normal renal function. All subjects received 48 weeks of therapy followed by 24 weeks of treatment-free follow-up.
Pancreatitis, sometimes fatal, has occurred during alpha interferon and ribavirin treatment. Some of these side effects may cause death. Inflammation of your pancreas pancreatitis. Patients should also pegasys package insert advised to consult their healthcare provider if the full dose is not received e. Dose reduction or discontinuation of PEGASYS, ribavirin or both should also be considered if worsening clinical toxicities are observed, including hepatic decompensation e.
Do not use the autoinjector pegasys package insert the medicine in it: Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine. Pick up the vial and syringe from your flat work surface.
Other Treatment Response Pegasys package insert Treatment response rates are lower in subjects with poor prognostic factors receiving pegylated interferon alpha therapy. All subjects were adults, had compensated liver disease, detectable hepatitis C virus HCVliver biopsy diagnosis of chronic hepatitis, and were previously untreated with interferon.
Updated June 26, Remove the needle from its package. Inflammation of your intestines colitis. PEGASYS combination treatment with ribavirin is pegasys package insert in women who are pregnant and men whose female partners are pregnant. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Development or exacerbation of autoimmune disorders including myositis, hepatitis, thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, psoriasis, rheumatoid arthritis, interstitial nephritis, thyroiditis, and systemic lupus erythematosus have been reported in patients receiving alpha interferon.
Find a well-lit, clean, flat surface such as pegasys package insert table.
These reactions may occur in patients pegasys package insert and without previous psychiatric illness. Preparation and administration in pediatric patients: Following improvement of the adverse reaction, neutropenia or thrombocytopenia, consider re-escalation of ppackage dosage back to the previous dosage [see Warnings and Precautions 5 and Adverse Reactions 6 ].
Genentech: Pegasys® (peginterferon alfa-2a) – Information for Patients
Pegasyys to reach the steady state in children is approximately 12 weeks, whereas in adults, steady state is reached within 5 to pegasys package insert weeks. The browser you are using, Internet Explorer 10, is no longer supported. Do not use the autoinjector if the expiration date pegasys package insert passed see Figure “B”.
Table 3 also includes recommended frequency of psychiatric visits.
WARNING: RISK OF SERIOUS DISORDERS
In addition, dose reduction or discontinuation of PEGASYS, ribavirin or both, should also be considered if worsening toxicities are observed [see Warnings and Precautions 5. They may be ineffective or may harm you.
Patients should be instructed to remain well hydrated, especially during the initial stages of treatment. Non-pegylated interferon alfa-2a packqge caused abortion when given to pregnant rhesus monkeys see Data. Pegylated recombinant human interferon alfa-2a is an insetr of the innate antiviral immune response [see Microbiology However, pegasys package insert prognostic factors occur pwgasys frequently in the US population than in the non-US population.
Do pegasys package insert use if the expiration date has passed see Figure A. If symptoms improve and are stable for 4 weeks, may resume normal visit schedule. How should I dispose of used syringes, needles, and vials? Treatment response rates are lower in subjects with poor prognostic factors receiving pegylated interferon alpha therapy. Never reuse disposable syringes and needles.
Pegasys package insert page may not render properly. After proper training in subcutaneous injection, a patient may subcutaneously self-inject with PEGASYS if a healthcare provider determines that it is appropriate [see Instructions for Use ]. packagw
Discard any unused portion remaining in the pegasys package insert, prefilled syringe. Ribavirin therapy should not be started unless a confirmed negative pregnancy test has been obtained immediately prior to initiation of therapy. Decrease insrt loss of vision, retinopathy including macular edema, retinal artery or vein thrombosis, retinal hemorrhages and cotton wool spots, optic neuritis, papilledema and serous retinal detachment are induced or aggravated by treatment insdrt PEGASYS or other alpha interferons.
Updates Package Inserts – Jan Pegasys can be purchased through a large number of outlets, including our Primary Wholesalers, their secondary wholesalers, and retail pharmacies. How should I give an injection? All subjects were followed for 24 weeks pegasys package insert.