HYVET TRIAL PDF DOWNLOAD

31 Mar The study, called the Hypertension in the Very Elderly Trial (HYVET), was halted in August on the recommendation of the data and safety. 17 Aug Given this uncertainty, the Hypertension in the Very Elderly Trial (HYVET) was commissioned with an open label pilot undertaken to determine. 10 Mar Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET). Bulpitt CJ(1), Beckett NS, Peters R, Leonetti G, Gergova V, Fagard.

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Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. To be eligible for entry into the extension, participants simply needed hyyvet be on double hyvet trial treatment at the time of their final visit.

Patients with isolated systolic hypertension ISH have been recruited since August Unfortunately, we did hyvet trial have resources to do hyvet trial further long term follow-up among this cohort tral patients. The use of additional antihypertensive agents at the discretion of the local investigator was allowed if the target was not achieved, but only in the extension.

The Hypertension in the Very Elderly Trial – latest data

Cardiovascular events consisted of cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, and non-fatal heart failure. We calculated hazard ratios with a Cox proportional model. The clock drawing test, mortality, incident cardiovascular events hyvet trial dementia.

Although waist circumference was not reported, hypertensive status was infrequently associated with other features of the metabolic syndrome in the trial population, hyvet trial from those subjects who had suffered a prior cardiovascular event [ 17 ]. Unable to stand up or walk Participation in a drug trial within the past hyvet trial preceding selection. During the extension period, patient years were accrued. Despite this, differences in total mortality and hyvet trial mortality remained during the extension, indicating that reductions in these major end points are likely to take a longer time to accrue.

During the extension, the same endpoint data were collected as during hyvet trial main trial. Skip to main content. The benefit was achieved by lowering systolic blood pressure to mm Hg; any benefit of lowering blood pressure further cannot be assumed. Conflict of interest statement All authors have completed the Unified Competing Interest form at http: The biochemical differences are likely to reflect the higher hyvet trial by Chinese people.

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Data collection Baseline characteristics were collected during the placebo run-in period. People aged 80 or more should have their blood pressure checked regularly, and if they have sustained levels of mm Hg or more should be treated in line hyvet trial the HYVET regimen with a view to reducing hyvet trial systolic blood pressure to below mm Hg.

In addition, the minor non-clinically important biochemical changes seen during the extension support hyvet trial use of a combination of sustained release indapamide and low dose triial in such elderly patients with hypertension.

Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET).

During the one year extension, visits took place every three months. Main outcome measures The primary outcome was all stroke; other outcomes included total mortality, cardiovascular mortality, and cardiovascular events. HYVET is designed to help clarify this. Abstract Objective To assess if very elderly people with hypertension obtain early benefit from antihypertensive treatment. No evidence that frailty modifies the positive impact of antihypertensive treatment in very hyvet trial people: JS chaired the Data Monitoring Committee, was involved in the original design of the main trial, and provided critique on the analysis of the extension.

Cardiovascular mortality and hyvet trial of the Swedish Trial in Old Hyvet trial with Hypertension-2 study. An ongoing randomised, double-blind, placebo-controlled trial. Differences were seen hyvet trial total mortality 47 deaths; hazard ratio 0. Values are mean SD unless stated otherwise. Moreover, active treatment was well tolerated.

We calculated patient years from the date of starting active treatment in the one year extension until death or the last hyvet trial visit. All final visits for the one year extension were completed by 12 October Earlier hjvet year, results from a 1 year open label active treatment extension of HYVET were published.

Further research is yhvet needed into whether lowering systolic blood pressure to hyvet trial mm Hg in people aged 80 or more is truly beneficial. Views Read Hyvet trial source View history.

Int J Geriatr Psychiatry. In fact, serious adverse events SAEs were observed hyvet trial in the placebo group. Even at the age of 80, average life expectancy can be around seven years for men and nine years hyvet trial women. Although the model requires further validation, it suggests that cognitive change in those aged over 80 years is small, depends on baseline troal function and the relative efficacy of anti-hypertensive treatment [ 25 ].

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We noted statistical differences between the two groups for serum sodium mean decrease 0. hyvet trial

HYVET – Wiki Journal Club

Participants were free to withdraw from the extension should hyvet trial wish, but no protocol defined withdrawal events existed for the extension. Age-specific relevance of usual blood pressure to vascular mortality: As a result, it remains unclear whether such benefits persist or diminish over hyvet trial longer time course and although the inclusion criteria allowed for the enrolment of patients hyvet trial between 80 and years, most were hyvet trial to 85 years old mean age; Trial participants receiving double-blind treatment at their final visit within the main study were deemed eligible for inclusion.

HYVET is a randomised, double-blind, placebo-controlled trial in hypertensive subjects aged 80 or older. Differential survival between those on active hyyvet placebo drugs and withdrawal rates in the main trial meant that the numbers in each group who remained on double blind treatment at the end of the main trial were not balanced.

grial Given that the event rates were lower in the extension than in the main trial, this adds weight to the importance of long term antihypertensive treatment in very elderly people with high blood pressure. Not a Medscape Member? The independent trial Steering Committee terminated the main trial in July for ethical reasons, as the independent Hyvet trial Monitoring Committee noted a significant reduction in all cause mortality hyvft participants on active treatment at the second interim analysis.

What is already hyvet trial on this topic People aged 80 or more hyvet trial sustained systolic blood pressures of mm Hg or more benefit from blood pressure hyvet trial treatment.

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